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Current study confirms the Nutritarian diet is BEST for reversing type 2 diabetes


For diabetics and pre-diabetics especially, new research proves what moms having been telling their children through the ages, “eat your veggies, they’re good for you.”  A recent study published in the British Journal of Nutrition reported that higher plant protein intake is associated with a reduced risk of type 2 diabetes. In their analysis, they estimated that replacing one percent of calories from animal protein with calories from plant protein would decrease the risk of type 2 diabetes by 18 percent.1

Animal protein: A diabetic culprit

At first glance, it may seem like the dietary effects on diabetes would be only relevant to carbohydrate-containing foods. The more low-carbohydrate, high-protein foods in your diet, the better; those foods don’t directly raise blood glucose. However, that is a too simplistic view of the development of type 2 diabetes. Type 2 diabetes is not only driven by elevated glucose levels, but also by chronic inflammation, oxidative stress, and alterations in circulating lipids (fats).2-5

In addition, there has been considerable amount of evidence that red and processed meats are linked to a greater risk of type 2 diabetes This recent study is not the first one to make the connection between protein source and diabetes. In fact, many studies have compared plant and animal protein intake with respect to diabetes risk. A larger study published in 2016 found an increase in type 2 diabetes risk in those with the highest animal protein intake. The study  also performed a meta-analysis of eleven previous studies, which detected a 19 percent increase in risk in the groups with the highest animal protein intake.6

A 2010 meta-analysis of 12 prospective cohort studies concluded that high total meat intake increased type 2 diabetes risk 17 percent above low intake, high red meat intake by 21 percent, and high processed meat intake by 41 percent.7 Since these foods don’t directly cause an increase in blood glucose, how might they raise diabetes risk?

Advanced Glycation End Products (AGEs):  a trigger diabetes factor

AGEs are substances that cause oxidative stress and inflammation, damage body proteins and fats, and contribute to heart disease, type 2 diabetes, and complications of diabetes. AGE production in the body is increased by elevated blood glucose.8-12  Food is also a source of AGEs, in particular, fried foods, broiled meats, high-fat animal foods, and dry cooked starchy foods (cookies, muffins, cold cereals, fried potatoes).13-15 If you compare meats to the major Nutritarian calorie sources – beans and raw nuts and seeds – a Nutritarian diet affords lower exposure to AGEs.

Excess heme iron: additional diabetes trigger factor

Too much iron increases the risk for type 2 diabetes. Heme iron, found only in animal products, is highly absorbable compared to nonheme iron in plant foods. A diet high in animal products over time results in excess body stores of iron.  A major connection between high heme iron intake and diabetes is that iron in excess has pro-oxidant properties; this can contribute to oxidative damage to pancreatic beta cells and insulin resistance. High dietary heme iron and high body stores of iron are associated with increased risk of type 2 diabetes.16  Nonheme iron (from plant foods) does not carry the same risk of excess because of its lower absorbability.

Good and bad fats: animal fats vs. plant fats

The types of fats we eat influence the fatty acids that circulate in our blood and compose our cell membranes, which affect insulin signaling and therefore diabetes risk. Clinical trials have shown that altering dietary fatty acids can alter insulin sensitivity. In these trials, saturated fats decreased insulin sensitivity, and monounsaturated fats either improved or did not affect insulin sensitivity. Omega-3 supplementation similarly either improved or did not affect insulin sensitivity.17-21

Animal protein and plant protein are indicators of animal foods and plant foods. Some will be lower or higher in fat, but animal foods generally have a greater ratio of saturated to unsaturated fats, suggesting that high animal food intake could negatively affect insulin sensitivity.

Importance of nutrient-rich foods:  eliminating meat is not enough

As shown, there are many negatives to animal foods when it comes to diabetes risk. However, it’s not simply an issue of avoiding meat; which plant foods you eat matters. Micronutrient-rich, whole plant foods are protective.  For example, a large analysis of the Nurses’ Health Study and Health Professionals Follow-Up Study (including over 200,000 participants) scored the participants’ diets based on a “healthful plant-based diet index,” in which foods like vegetables, legumes, fruits, nuts, and whole grains increased the score and foods like fruit juices, sweetened beverages, refined grains, potatoes, sweets, and animal foods decreased the score.

They also constructed an unhealthful plant-based diet index (uPDI), in which unhealthful plant foods increased the score, and healthful plant foods and animal foods decreased the score. The healthful plant-based diet index was strongly negatively associated with type 2 diabetes, meaning the healthful plant-based dieters had a lower incidence of type 2 diabetes. The unhealthful plant-based diet index was positively associated with type 2 diabetes, meaning that a diet with a lot of fruit juices, sweetened beverages, refined grains, potatoes, and sweets – even if low in animal foods – increased risk.22

High fiber, micronutrient, and phytochemical intake helps prevent or reverse type 2 diabetes

A healthy diet must be composed mostly of whole, fiber-rich, high-nutrient plant foods.  It’s not enough to eat a vegan diet; even if only a small amount of animal products is included. My decades of experience caring for people with type 2 diabetes has enabled over 90 percent of them to become non-diabetic; this has been documented in medical publications. In a study of patients with type 2 diabetes following a Nutritarian diet, after one year 90 percent of participants were able to eliminate or reduce their diabetes medications, and the mean HbA1c was 5.8 percent, which is in the normal (non-diabetic) range.23

Every physician caring for patients with diabetes and pre-diabetes, as well as patients themselves must be informed about this life-saving approach, as described in my book The End of Diabetes. Type 2 diabetes is reversible in the vast majority of cases, and those with type 1 diabetes can improve their life expectancy, health and quality of life.

 
References
  1. Virtanen HEK, Koskinen TT, Voutilainen S, et al. Intake of different dietary proteins and risk of type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Br J Nutr 2017, 117:882-893.
  2. Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 2011, 50:567-575.
  3. Chen L, Chen R, Wang H, Liang F. Mechanisms Linking Inflammation to Insulin Resistance. Int J Endocrinol 2015, 2015:508409.
  4. Keane KN, Cruzat VF, Carlessi R, et al. Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and beta-Cell Dysfunction. Oxid Med Cell Longev 2015, 2015:181643.
  5. Glass CK, Olefsky JM. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab 2012, 15:635-645.
  6. Shang X, Scott D, Hodge AM, et al. Dietary protein intake and risk of type 2 diabetes: results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies. Am J Clin Nutr 2016, 104:1352-1365.
  7. Aune D, Ursin G, Veierod MB. Meat consumption and the risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies. Diabetologia 2009, 52:2277-2287.
  8. Peppa M, Raptis SA. Glycoxidation and Wound Healing in Diabetes: An Interesting Relationshi. Curr Diabetes Rev 2011.
  9. Peppa M, Stavroulakis P, Raptis SA. Advanced glycoxidation products and impaired diabetic wound healing. Wound Repair Regen 2009, 17:461-472.
  10. Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 2006, 114:597-605.
  11. Yamagishi S, Matsui T. Advanced glycation end products, oxidative stress and diabetic nephropathy. Oxid Med Cell Longev 2010, 3:101-108.
  12. Nowotny K, Jung T, Hohn A, et al. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules 2015, 5:194-222.
  13. Goldberg T, Cai W, Peppa M, et al. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc 2004, 104:1287-1291.
  14. Pruser KN, Flynn NE. Acrylamide in health and disease. Front Biosci (Schol Ed) 2011, 3:41-51.
  15. Uribarri J, Woodruff S, Goodman S, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc 2010, 110:911-916 e912.
  16. Simcox JA, McClain DA. Iron and diabetes risk. Cell Metab 2013, 17:329-341.
  17. Corcoran MP, Lamon-Fava S, Fielding RA. Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise. Am J Clin Nutr 2007, 85:662-677.
  18. Paniagua JA, de la Sacristana AG, Sanchez E, et al. A MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in insulin-resistant subjects. J Am Coll Nutr 2007, 26:434-444.
  19. Due A, Larsen TM, Hermansen K, et al. Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets. Am J Clin Nutr 2008, 87:855-862.
  20. Lalia AZ, Lanza IR. Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation? Nutrients 2016, 8.
  21. Vessby B, Uusitupa M, Hermansen K, et al. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia 2001, 44:312-319.
  22. Satija A, Bhupathiraju SN, Rimm EB, et al. Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies. PLoS Med 2016, 13:e1002039.
  23. Dunaief DM, Fuhrman J, Dunaief JL, Ying G. Glycemic and cardiovascular parameters improved in type 2 diabetes with the high nutrient density (HND) diet. Open Journal of Preventive Medicine 2012, 2.
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